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Liverpool will meet Merseyside rivals Everton in the third round of the FA Cup.
League Two Newport, FA Cup conquerors of Leicester and Middlesbrough last season, visit Millwall, with all-Championship ties including Swansea's trip to QPR, Charlton hosting West Brom and Brentford tackling Stoke.
Jurgen Klopp's Premier League leaders will have home advantage in the cup Merseyside derby, which will take place from 3-6 January.
Leicester, second in the Premier League, entertain Wigan, with Frank Lampard's Chelsea welcoming Nottingham Forest to Stamford Bridge.
Premier League relegation candidates Watford host League One Tranmere, Southampton are at home to Huddersfield and Brighton meet Sheffield Wednesday.
Holders Manchester City landed a home tie against Port Vale, while Manchester United will visit Wolves, the club that knocked them out of last season's competition at the quarter-final stage.
National League AFC Fylde will mark their first third-round appearance with a trip to Sheffield United, with National League North Boston hosting Newcastle if they beat Rochdale in a second-round replay.
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