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With no.1 goalkeeper Alisson suspended, Klopp is forced to start deputy Adrian between the sticks, but has also made some huge calls elsewhere in the line-up.
Jurgen Klopp has made five changes from the Liverpool side that beat Brighton at the weekend for the season's first Merseyside derby.
Toffees boss Marco Silva was given a stay of execution despite Sunday's late defeat at Leicester, but a heavy loss against the Reds could prove the final nail in his coffin.
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Alex Oxlade-Chamberlain is also omitted from the starting XI as James Milner, Adam Lallana, Xherdan Shaqiri and Divock Origi all get the nod.
Captain Jordan Henderson and two of the Reds' regular front three, Roberto Firmino and Mohamed Salah, start on the bench.
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